Columbia University Medical Center
NewYork-Presbyterian Hospital The University Hospital of Columbia and Cornell

Experimental Therapeutics

Daniel C. Javitt, MD, PhD, Director

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The Division of Experimental Therapeutics focuses on development of new treatment approaches for schizophrenia, depression and other severe mental disorders.  This division was formed in 2011 by combining the Divisions of Brain Stimulation with a newly created Conte Center for Schizophrenia Research.  The Division interacts closely with the Lieber Clinic to conduct early phase clinical studies of novel therapeutic agents, and with the C.O.P.E. Clinic to perform neurophysiological, neuroimaging treatment studies in the schizophrenia prodrome.

The current Program in Brain Stimulation conducts studies using multiple brain stimulation modalities, including Deep Brain Stimulation (DBS), Transcranial magnetic stimulation (TMS), transcranial Direct Current Stimulation (tDCS), magnetic seizure therapy (MST) and electroconvulsive therapy (ECT) for depression, OCD, schizophrenia, cerebral palsy and other disorders.  The Program in Brain Stimulation also maintains a clinical program in TMS and ECT, and conducts highly popular CME programs in ECT and TMS.

The Columbia Conte for Schizophrenia Research conducts neurophysiological and neuroimaging investigations into brain mechanisms underlying schizophrenia and other severe mental disorders.  Research activites are divided between Columbia University and Nathan Kline Institute for Psychiatric Research.  The Center has been at the forefront of investigating the role of glutamatergic /N-methyl-D-aspartate receptor (NMDAR) dysfunction in the pathophysiology of schizophrenia, depression and other disorders and development of novel NMDAR based treatments. 

The Division interacts closely with the Lieber Clinic to conduct early phase clinical studies of novel therapeutic agents, and with the C.O.P.E. Clinic to perform neurophysiological, neuroimaging treatment studies in the schizophrenia prodrome. 

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