Columbia University Medical Center
NewYork-Presbyterian Hospital The University Hospital of Columbia and Cornell
Researchers using light to activate neurons, make mice obsessive - or not
June 6, 2013 - June 10, 2013

To figure out if the circuit disruptions observed in OCD patients are a cause or effect of the disorder, Susanne Ahmari, a neuroscientist and psychiatrist at Columbia University, and colleagues used optogenetics to stimulate in mice a neural circuit known to be hyperactivated in OCD patients. They expected to see repetitive behavior in the mouse as soon as they stimulated the circuit, but they didn’t. “This was a surprise to us,” says Ahmari. “The direct activation did not lead to repetitive behaviors in the mice.” But when they repeatedly stimulated the neural circuits, the mice developed obsessive behaviors.

 

 http://www.technologyreview.com/news/515731/researchers-using-light-to-activate-neurons-make-mice-obsessive-or-not/

 

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