Columbia University Medical Center
NewYork-Presbyterian Hospital The University Hospital of Columbia and Cornell

Studies for Depression

Antidepressant Response in Late-Life Depression

In this research study, you may receive treatment for depression with an FDA approved medication called escitalopram (Lexapro) or placebo. Escitalopram is a Selective Serotonin Reuptake Inhibitor (SSRI) medication that appears to help with symptoms of depression by increasing the availability of specific chemicals in the brain. A placebo is a sugar pill. The purpose of this study is to determine how treatment response may change depending on how studies are designed. Participants in this study will also undergo Magnetic Resonance Imaging (MRI) in order to investigate the brain responses associated with depression.

Study Activities

  • Filling Out Forms
  • Blood Samples
  • MRI Scan

Eligibility

  • Ages Eligible for Study: 60 Years - 90 Years
  • Genders Eligible for Study: Both
  • This study is not recruiting Healthy Volunteers.

For more information, please contact Natalia Hepp at Tel: 646-774-8664.


Treatment of Depression: Cognitive and Neural Mechanisms

The goal of this study is to understand factors related to symptomatic improvement in patients with depression. Referred patients will receive a full evaluation by a psychiatrist and trained psychiatric rater. Eligible patients will be offered the opportunity to participate in an 8 week long clinical trial in which they may be prescribed an FDA approved antidepressant. Patients are also eligible for 3 months of free open treatment following their participation in the acute study.

Study Activities

  • Filling Out Forms
  • Computer Tasks
  • Blood Samples
  • MRI Scan
  • Provides Payment: Compensation for study related procedures

Eligibility

  • Ages Eligible for Study: 24 Years - 75 Years
  • Genders Eligible for Study: Both
  • This study is recruiting Healthy Volunteers.

For more information, please contact Emily Pott at 646-774-8652.


A Comparison of Medication Augmentation and Problem Solving Therapy in the Treatment of Depression in Older Adults

The purpose of this study is to compare the effectiveness of two different augmentation strategies of antidepressant treatment for depressed older adults who have not responded to an adequate trial of antidepressant medication. The first augmentation strategy is Problem Solving Therapy (PST), a 12-week psychotherapy treatment that has been shown to be effective in depressed older adults. The second augmentation strategy is (FDA approved) medication augmentation, which will begin with six weeks of aripiprazole, an atypical antipsychotic medication that has also been shown to be effective in depressed older adults who have failed a trial of antidepressant medication. If patients have not completely improved at the end of the 6 week aripiprazole trial, they will be switched to treatment with bupropion for the remaining 6 weeks of the study. The acute phase of the study is followed by 3 months of free open treatment.

Study Activities

  • Filling Out Forms
  • Blood Samples

Eligibility

  • Ages Eligible for Study: 50 Years - 90 Years
  • Genders Eligible for Study: Both
  • This study is not recruiting Healthy Volunteers

For more information, please contact Emily Pott at 646-774-8652.


Developing New Clinical Management Strategies for Antidepressant Treatments

The goal of this study is to develop new methods of administering antidepressant medications that will result in enhanced medication response in clinical treatment. A “one size fits all” approach to psychopharmacologic management (i.e., weekly visits for all patients) does not take into account differences between patients that may predispose some individuals to respond positively to frequent follow-up visits, while others may respond negatively or not at all. In this study, patients are treated with escitalopram (Lexapro, an FDA approved SSRI medication for depression) or placebo, and come in for visits either on a weekly or a monthly basis for 8 weeks. The trial is followed by 3 months of free open treatment.

Study Activities

  • Filling Out Forms
  • Blood Samples

Eligibility

  • Ages Eligible for Study: 18 Years - 60 Years
  • Genders Eligible for Study: Both
  • This study is not recruiting Healthy Volunteers

For more information, please contact Emily Pott at 646-774-8652.

 

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