Study Name: High Affinity Serotonin 1A Receptor Binding in Major Depression
Principal Investigator: Dr. J. John Mann, M.D.
Purpose of Study: We will study 110 participants using PET scans to identify changes in brain chemistry that may contribute to episodes of major depression. Positron Emission Tomography (PET) scans provide "pictures" of chemical activity in the brain using a chemical with a radioactive tag attached. Some people will be scanned twice, before and after treatment, to determine the effect of treatment on brain chemistry. We will be comparing brain scans from this study between individuals suffering from depression and volunteers without depression.
Treatment Offered: We offer up to six months of outpatient medication-based treatment after the study. Patients will be responsible only for the cost of medication for depression. If treatment is still needed after this time has passed, referrals will be given for continuing treatment elsewhere. If a patient has major depressive disorder and is interested in receiving treatment with psychotherapy instead of medication, they may be eligible to enroll in another of our studies as well, “Predictors of Treatment Outcome with Cognitive Behavioral Therapy for Depression,” which offers twelve weeks of psychotherapy.
Eligibility: Men and Women ages 18-65. We enroll individuals suffering from depression as well as volunteers without depression. Volunteers without depression will complete brain imaging, but will not receive antidepressant treatment.
Funding: NIH Grant MH040695
Contact information: Corinne Bart